PhotoLast month, we reported on a study which showed that overeating leads to even more eating. The premise of the research was that eating too much in one sitting suppresses a hormone that tells your brain that you’re full.

Now, a new study conducted by the University of Georgia, Binghamton University, and Pennsylvania State University have reached similar conclusions. Researchers found that foods that are high in fat disturb neural messages to the brain that allow you to feel full. However, they believe that manipulating microbes in the stomach may reverse the effect.

Stifled communication

The study involved examining the “gut-to-brain” neural pathways in mice, who were sustained on a high-fat diet. The researchers found that regions of the brain responsible for processing feeding behavior became inflamed when high amounts of fat were introduced.

In order to determine the cause, they began examining microbiota in the stomach to see if the diet influenced composition. After finding a connection, lead researcher Dr. Claire de La Serre and her colleagues began injecting mice with low doses of a spectrum antibiotic that was able to reverse the negative effects.

Potential impact

There is potential for the impact of this study to be great. It precisely demonstrates to what extent stomach microbiota are affected by a high-fat diet. Information gleaned from the research could allow the medical community to come up with new therapies and medications that counter trends in overeating and obesity, two major health concerns.

One additional study has already made some progress by showing that eating certain types of foods can benefit microbiota composition in the stomach. Researchers found that eating blueberries, which have high levels of anthocyanin, can help lessen inflammation and lead to more stable blood sugar levels. Additional research into other bioactive foods will almost certainly follow.

Research conducted by De la Serre et al is scheduled to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), which takes place from July 12-16.  

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