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FDA recinds order blocking Juul’s e-cigarette marketing

The agency will take another look at the vaping product

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The U.S. Food and Drug Administration (FDA) has done an about face, recinding its marketing denial order (MDO) against Juul e-cigarettes, nearly two years after issuing.

In July 2022, the FDA blocked Juul from advertising its e-cigarette products in the U.S., after the agency determined that Juul’s documentation “lacked sufficient evidence regarding the toxicological profile of the products to demonstrate that the marketing of the products met the public health standard ...

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    E-cigarettes cause inflammation in the gut and can lead to health problems, study finds

    A study provides new evidence of the health costs of vaping

    A new study conducted by researchers from the University of California at San Diego found yet another health risk associated with smoking e-cigarettes

    According to their findings, consumers who vape are increasingly more susceptible to a condition known as leaky gut. This happens when holes have developed in the gut lining that bacteria can leak through, which can ultimately cause inflammation throughout the entire body. 

    “This is the first study that demonstrates how chronic exposure to e-cigarettes increases the gut’s susceptibility to bacterial infections, leading to chronic inflammation, and other health concerns,” said researcher Soumita Das, PhD. “Given the importance of the gut barrier in the maintenance of the body’s immune homeostasis, the findings provide valuable insight into the potential long-term harmful effects chronic use of e-cigarettes [has] on our health.” 

    Risks to gut health

    To better understand how gut health is impacted by e-cigarettes, the researchers created 3D models of the human intestinal system using stem cells. They then used the models to mimic the process of smoking an e-cigarette and analyzed the effects of smoking on the models’ gut reaction. 

    The researchers found that chemical additives used in e-cigarettes -- specifically propylene glycol and vegetable glycerol -- are responsible for damage to the intestines. Ultimately, these chemicals damage the gut’s protective barrier, which is what initiates gut inflammation. 

    While this is concerning for overall gut health, the researchers explained that it can also have greater complications for consumers’ immune systems. Once these chemicals break through the intestines, they have direct access to the immune system, which can make consumers more susceptible to infections. 

    “The safety of e-cigarettes has been debated fiercely on both sides,” said researcher Dr. Pradipta Ghosh. “Nicotine content, and its addictive nature, has always been the major focus of those who argue against its safety, whereas lack of chemicals in the carcinogens that are present in the cigarette smoke has been touted by the makers of e-cigarettes when marketing these products as a ‘healthy alternative.’ In reality, it’s the chemicals making up the vapor liquid that we should be more concerned about as they are the cause of gut inflammation.” 

    Though vaping rates have declined in recent months -- especially for young people -- the researchers hope that consumers understand the severity of the long-term risks associated with smoking e-cigarettes. 

    “The gut lining is an amazing entity,” said researcher Dr. Ghosh. “It is comprised of a single layer of cells that are meant to seal the body from trillions of microbes, defend our immune system, and at the same time allow absorption of essential nutrients. Anything we eat or drink, our lifestyle choices in other words, has the ability to impact our gut microbes, the gut barrier, and overall health. Now we know that what we smoke, such as e-cigarettes, negatively impacts it as well.” 

    A new study conducted by researchers from the University of California at San Diego found yet another health risk associated with smoking e-cigarettes....

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    Vaping could harm cognitive function and thinking ability, study finds

    Researchers worry about the effect on young people’s brain development

    As more and more studies highlight the health concerns associated with vaping -- which include serious lung damage and heart issues -- a new study conducted by researchers from the University of Rochester Medical Center is exploring how e-cigarettes can affect consumers’ mental function. 

    According to their findings, vaping can have a negative effect on memory, thinking skills, and the ability to focus. The researchers say they are most worried about young people who vape. 

    “Our studies add to growing evidence that vaping should not be considered a safe alternative to tobacco smoking,” said researcher Dongmei Li, PhD. 

    Issues with cognitive function

    The researchers conducted two studies to help them better understand what effect vaping has on consumers’ mental faculties. One study analyzed data from over 886,000 participants involved in the Behavioral Risk Factor Surveillance System Survey, and the other study looked at more than 18,000 responses to the National Youth Tobacco Survey. 

    Ultimately, the researchers learned that participants who vaped or smoked cigarettes were more likely to struggle with cognitive function than those who had never smoked in any capacity. The study revealed that smoking -- whether e-cigarettes or traditional cigarettes -- was associated with three primary cognitive issues: decision-making, memory, and concentration. 

    Additionally, the researchers explained that age played a large role in the participants’ cognitive abilities. They found that when participants were younger than 14 when they started vaping or smoking, they were even more likely to have cognitive struggles as adults. 

    Though vaping rates for young people have declined in the last year, and many companies have put age restrictions on e-cigarettes to help prevent young people from picking up the habit, a great deal of e-cigarette advertising has previously been geared towards the younger demographic. The researchers are particularly concerned because high school age is a pivotal time in the brain’s development process. If young people have already picked up a smoking habit by this age, it could affect brain function long-term. 

    “With the recent rise in teen vaping, this is very concerning and suggests that we need to intervene even earlier,” said Dr. Li. “Prevention programs that start in middle or high school might actually be too late.” 

    As more and more studies highlight the health concerns associated with vaping -- which include serious lung damage and heart issues -- a new study conducte...

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    Flavors added to e-cigarettes can lead to lasting heart damage, study finds

    Experts say that young people are most attracted to the wide variety of flavor options

    There is no shortage of research highlighting the health risks associated with vaping -- especially when looking at the additives that are particularly popular among younger consumers. 

    A new study conducted by researchers from the University of South Florida has explored the flavor additives even further, and it found that these chemicals can increase the risk of lasting heart damage.

    “The flavored electronic nicotine delivery systems widely popular among teens and young adults are not harm-free,” said researcher Sami Noujaim, PhD. “Altogether, our findings in the cells and mice indicate that vaping does interfere with the normal functioning of the heart and can potentially lead to cardiac rhythm disturbances.”

    Compromising heart health

    The researchers conducted experiments on both young mice and human cardiac cells to better understand how flavor additives in e-cigarettes can compromise heart health. In all of the trials, both the mice and the human cells were exposed to several different flavor additives, as well as e-vapors that didn’t contain flavorings, to understand how the health risks change. 

    While e-cigarettes pose a threat to consumers’ health without adding flavors, the researchers learned that the flavor additives only exacerbated those health risks in both mice and human cells. 

    For the mice, the researchers observed several changes to their normal heart functioning. The primary disturbance was heart rate, as the mice exposed to e-cigarette flavor additives were more likely to develop ventricular tachycardia, which speeds up the natural heart rate. However, other mice were also more susceptible to a slowed heart rate variability, which means the time between heartbeats is slower; this typically happens when the body is under stress, and it can increase the risk for heart disease over time. 

    The researchers noted similar effects to the human cardiac cells. Even before exposing the cells to the flavor additives, the e-cigarette vapor alone affected how fast the cells were able to beat. As the researchers added both nicotine and flavoring, the cells became even more compromised, though the worst outcomes came from the addition of the flavoring.  

    “This experiment told us that the flavoring chemicals added to vaping devices can increase harm beyond what the nicotine alone can do,” Dr. Noujaim said. 

    Tightening restrictions

    Despite efforts to regulate e-cigarettes -- especially in recent months as experts warned about the risks associated with the COVID-19 pandemic -- many young people continue to seek out flavored vaping options. The researchers hope that these findings can help cut down on the use of e-cigarettes among this demographic.

    “Our research matters because regulation of the vaping industry is a work in progress,” said Dr. Noujaim. “The FDA needs input from the scientific community about all the possible risks of vaping in order to effectively regulate electronic nicotine delivery systems and protect the public’s health. At USF Health, in particular, we will continue to examine how vaping may adversely affect cardiac health.”

    There is no shortage of research highlighting the health risks associated with vaping -- especially when looking at the additives that are particularly pop...

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    Youth vaping rates have declined during the COVID-19 pandemic

    Lung health concerns were a key factor for teens who decided to cut back or quit

    Youth vaping rates plunged during the COVID-19 lockdown period, according to a new survey published Thursday in JAMA Network Online. 

    Roughly two-thirds (35 percent) of teen and young adult e-cigarette users said they reduced their use of the products or stopped using them altogether (32 percent). The survey found that concerns about lung health were a key factor for 1 in 4 respondents who said they either cut back or quit. 

    Concerns about COVID-19 (which affects the lungs) have combined with concerns stemming from last year’s nationwide outbreak of a condition dubbed “EVALI,” short for “e-cigarette- or vaping-associated lung injury.” 

    "One of the main reasons they quit is that they were worried about lung health, and we think that's important, that they thought they could hurt their lungs," said lead researcher Bonnie Halpern-Felsher, a developmental psychologist and professor of pediatrics at Stanford University in California.

    Kids adhered to stay-at-home orders were 50 percent more likely to quit or reduce their vaping, researchers found. However, only 15 percent of respondents said they were motivated to quit for fear of their parents finding out about their vaping.  

    Emphasizing adverse health effects

    Doctors and health officials say the study results suggest that emphasizing the health risks of vaping is an effective way to get younger users to stop using the products. Although teen vaping has become less of a concern in light of the COVID-19 pandemic, experts say it’s still a major problem. 

    “Vaping is still an important issue just as I think smoking is still an important issue … We've sort of forgotten about it because we've had a bigger health concern to worry about,” Dr. Nancy Rigotti, director of the Tobacco Research and Treatment Center at Massachusetts General Hospital in Boston, told TODAY.

    Experts say vaping use among teens could rise again after the pandemic is over and normal social events are cleared to resume. Halpern-Felsher said e-cigarette use among minors is largely socially driven, so the problem could resurface once kids can congregate safely.

    "The concern is that as soon as youth are not having sheltering in place and they're all back in school, whether we're going to see more social use again and the uptick will happen," she said.

    Highlighting research showing the health effects of vaping can be an effective way to get e-cigarette users to re-think their decision to start using the products in the first place. 

    "If we can emphasize that vaping is not healthy and make it appear unattractive, we will win over this generation of e-cigarette users. We'll get them to stop,” said Dr. Panagis Galiatsatos, director of the Johns Hopkins Tobacco Treatment Clinic in Baltimore.

    Youth vaping rates plunged during the COVID-19 lockdown period, according to a new survey published Thursday in JAMA Network Online. Roughly two-thirds...