2025 Diabetes

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CDC reports rise in prediabetes among children aged 12 to 17

  • Nearly 1 in 5 U.S. teens aged 12–17 has prediabetes, according to the CDC's latest analysis.

  • The data underscores a significant silent epidemic, with most affected adolescents unaware of their condition.

  • Health experts urge increased screenings, especially for at-risk groups, and better public awareness.


A new analysis from the Centers for Disease Control and Prevention (CDC) has identified a troubling trend: nearly 1 in 5 American adolescents between the ages of 12 and 17 is living with prediabetes. 

The findings are based on data collected from the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample that combines interviews, physical exams, and laboratory testing.

Prediabetes, a condition in which blood sugar levels are elevated but not yet high enough to qualify as type 2 diabetes, is considered a major warning sign. In the CDC analysis, prediabetes was diagnosed using two key indicators: a fasting plasma glucose (FPG) level between 100 and 125 mg/dL, or a hemoglobin A1c level between 5.7% and 6.4%. Adolescents already diagnosed with diabetes were excluded from the analysis.

What makes the situation more alarming is that prediabetes typically occurs without symptoms, especially in younger populations. That means many adolescents and their families may be unaware of the metabolic changes occurring, despite the long-term health risks they pose, including progression to type 2 diabetes, heart disease, and kidney complications.

Behind the numbers

The CDC used updated FPG calibration methods to ensure accuracy across multiple NHANES data collection cycles. Older prediabetes estimates—such as the 2020 study by Andes et al.—used a different adjustment method, making this new analysis a more refined look at how widespread the issue has become.

To confirm diabetes status, researchers relied on both interview responses and lab results. Adolescents were classified as diabetic if they either answered “yes” to having been diagnosed by a healthcare provider or had lab-confirmed results with FPG ≥126 mg/dL or A1c ≥6.5%.

Physicians say the findings underscore the urgent need for earlier interventions, particularly as lifestyle factors like sedentary behavior, poor diet, and obesity continue to climb among youth populations. The CDC and other public health organizations have long recommended increased screening for children with risk factors such as obesity, family history of diabetes, or signs of insulin resistance.

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Xylitol linked to increased blood clot risk

Losing weight is something nearly every American wants to do but, like a lot of things, it's not always good for your health. Case in point: xylitol, the sugar substitute that's used in a lot of low-calorie foods.

Consumers with diabetes and those trying to lose weight choose artificial sweeteners to safeguard their health. But now, a new study by Cleveland Clinic researchers published in the European Heart Journal finds that xylitol carries an increased risk of heart attack and stroke.  

The study, published this week, examined the effects of xylitol on blood clotting and cardiovascular events. While researchers caution that their findings do not prove cause-and-effect, the results indicate a strong association between xylitol levels and cardiovascular risk.

Xylitol and cardiovascular events

The first part of the study analyzed blood plasma samples from over 3,000 fasting individuals who had participated in an earlier study. These individuals had been followed for three years, and some had experienced major cardiovascular events such as heart attacks or strokes.

When comparing their blood samples, researchers found that those who suffered a cardiovascular event had significantly higher blood levels of xylitol than those who did not.

How Xylitol affects blood clotting

To further explore the potential risks, researchers conducted lab tests on human blood and mice models.

  • In human blood samples, they found that xylitol increased platelet activity, causing the blood to clot more easily.
  • In mice, they injured the carotid artery and observed an accelerated rate of clot formation in those exposed to xylitol.

Since blood clots can travel to arteries and veins in major organs, they can increase the risk of heart attacks, strokes, and even death.

Testing on volunteers

The researchers also conducted a small human trial to test how quickly xylitol could affect blood clotting. They gave 10 healthy volunteers a drink sweetened with xylitol and measured their blood clotting ability before and 30 minutes after consumption.

  • Results showed a rapid increase in clotting ability in those who consumed the xylitol drink.
  • In contrast, volunteers who drank glucose or other sugar-sweetened beverages showed no changes in blood clotting.

What it means for consumers

While the findings are concerning, researchers stress that the study does not prove xylitol directly causes heart attacks or strokes.

“We need to determine whether this effect is unique to xylitol or common among all sugar alcohols,” said Dr. Stanley Hazen, a cardiologist and lead researcher of the study.

Until more research is done, experts advise consumers to be mindful of sugar substitutes and their potential health risks.