Researchers Find Annual Mammograms Starting at Age 40 is Best

A new study questions the controversial U.S. Preventive Service Task Force recommendations for breast cancer screening, with data that shows starting at a younger age and screening more frequently will result in more lives saved.

Back in November 2009, the task force recommended women ages 50 to 74 should undergo mammogram screenings every two years.

This controversial recommendation differed from the American Cancer Society’s guidelines which recommend yearly mammograms for women starting at age 40.

The study, conducted by R. Edward Hendrick, Ph.D., clinical professor of radiology at the University of Colorado School of Medicine, and Mark Helvie, M.D., director of breast imaging at the University of Michigan Comprehensive Cancer Center, analyzed the same data looked at by the task force and compared the task force’s recommendations to the American Cancer Society’s.
 
Hendrick and Helvie used six model scenarios of screening mammography created by the Cancer Intervention and Surveillance Modeling Network. This is the same modeling data the task force considered.

The authors found if women begin yearly mammograms at age 40, it reduces breast cancer deaths by 40 percent.

When screening begins at 50 and occurs every other year, it reduces breast cancer deaths 23 percent.

71% improvement 

The difference between these two screening strategies comes down to 71 percent more lives saved with yearly screening beginning at 40.

Helvie said the task force guidelines created confusion among women, leading some to forego mammography altogether.

“Mammography is one of the few screening tools that has been proven to save lives and our analysis shows that for maximum survival, annual screening beginning at 40 is best. This data gives women more information to make an informed choice about the screening schedule that’s best for them,” said Helvie.
 
As part of their recommendation, the task force emphasized the potential harms mammography can cause -- including pain during the screening exam and anxiety from false-positives, which can lead to additional imaging or biopsy.
 
Hendrick and Helvie found, on average, women ages 40 to 49 who are screened annually will have a false-positive mammogram once every 10 years. They will get asked back for more tests once every 12 years and will undergo a false-positive biopsy once every 149 years.
 
Hendrick said the task force overemphasized the potential harms of screening mammography, while ignoring the proven statistically significant benefit of annual screening mammography starting at age 40.

“In addition, the panel ignored more recent data from screening programs in Sweden and Canada showing that 40 percent of breast cancer deaths are averted in women who get regular screening mammography. Our modeling results agree completely with these screening program results in terms of the large number of women lives saved by regular screening mammography,” he said.
 
Helvie’s and Hendrick’s study appears in the February issue of the American Journal of Roentgenology.