Researchers have found as the years go on, the cases of gout -- a common and painful inflammatory arthritis -- have grown from 16 out of every 100,000 women in 1977 to 42 out of every 100,000 in 1996.
Sure, those aren't huge numbers, but it's an increase that has health care professionals concerned.
"The increasing disease burden of gout in the United States over the last few decades... coincided with a substantial increase in soft drink and fructose consumption," the study authors wrote.
While data on the relationship between high consumption of fructose and gout is limited, the study authors point out that drinks like sweetened sodas and orange juice can increase uric acid in the blood. Too much uric acid in the system is a known cause of gout.
Hyon K. Choi, M.D., Dr.P.H., of the Boston University School of Medicine, and colleagues examined the relationship between intake of fructose-rich beverages and fructose and incidence of gout in a large group of women.
The study consisted of data from the Nurses' Health Study, a U.S. prospective cohort study spanning 22 years (1984-2006). The researchers analyzed data from 78,906 women with no history of gout at the beginning of the study and who provided information on intake of beverages and fructose through validated food frequency questionnaires.
22 years
During 22 years of follow-up, the researchers documented 778 newly diagnosed cases meeting American College of Rheumatology survey criteria for gout. They found that increasing intake of sugar-sweetened soda was associated with increasing risk of gout.
Compared with consumption of less than 1 serving per month, women who consumed one serving per day had a 74 percent increased risk of gout; and those with 2 or more servings per day had a 2.4 times higher risk.
Fans of diet soda can rest, however -- those were not associated with the risk of gout.
Orange juice intake was also associated with risk of gout. Compared with women who consumed less than a glass (6 oz.) of orange juice per month, women who consumed 1 serving per day had a 41 percent higher risk of gout, and there was a 2.4 times higher risk with 2 or more servings per day.
Also, compared with women in the lowest quintile (fifth) of free fructose intake, women in the highest quintile had a 62 percent higher risk of gout.
The authors note that although the relative risks of gout associated with fructose-rich beverages among women were substantial, the corresponding absolute risk differences were modest given the low incidence rate of gout among women.
The researchers add that their findings have practical implications for the prevention of gout in women, and that physicians should be aware of the potential effect of these beverages on the risk of gout.
"Our data provide prospective evidence that fructose poses an increased risk of gout among women, thus supporting the importance of reducing fructose intake," the study authors wrote.
The study that will appear in the November 24 print edition of JAMA and is being released early online to coincide with its presentation at the American College of Rheumatology annual scientific meeting.
