Drug companies spend millions on ads touting their latest drugs, hoping you'll ask your doctor to write prescriptions for them. But before you ask for the latest blood pressure medication, consider this:
Expensive brand-name medications to lower blood pressure are no better at preventing cardiovascular disease than older, generic diuretics, according to new long-term data from a landmark study.
Paul Whelton, MD, president and CEO of Loyola University Health System, reported the results today at the China Heart Congress and International Heart Forum in Beijing.
More than 33,000 patients with high blood pressure were randomly assigned to take either a diuretic (chlorthalidone) or one of two newer drugs, a calcium channel blocker (amlodipine) or an ACE inhibitor (lisinopril).
In 2002, researchers reported that among patients followed for four-to-eight years, the diuretic was better than the calcium channel blocker in preventing heart failure and better than the ACE inhibitor in preventing stroke, heart failure and overall cardiovascular disease.
Longer-term study
In the new study, researchers followed study participants for an additional four to five years after completion of the trial, bringing the total follow-up period to between eight and 13 years. During this longer follow-up period, the differences among the three drugs narrowed; by most measures they were a statistical dead heat.
But the diuretic still was superior in two measures: Compared with the diuretic group, the ACE inhibitor group had a 20 percent higher death rate from stroke, and the calcium channel blocker group had a 12 percent higher rate of hospitalizations and deaths due to heart failure.
Diuretics, sometimes called "water pills," are the traditional medications for high blood pressure. They cause kidneys to remove sodium and water from the body, thereby relaxing blood vessel walls.
ACE inhibitors such as lisinopril (brand names, Prinivil and Zestril) decrease chemicals that tighten blood vessels. Calcium channel blockers such as amlodipine (brand name, Norvasc) relax blood vessels.
Significant savings
Diuretics cost $25 to $40 per year, while newer brand-name hypertension drugs can cost $300 to $600 per year.
The National Heart, Lung and Blood Institute recommends patients control their blood pressure by first controlling their weight, exercising, reducing sodium, increasing potassium and drinking alcohol in moderation. The institute says that if lifestyle changes are not sufficient, diuretics then normally should be the drug of first choice.
However, newer, higher-priced drugs are heavily marketed, and diuretics account for only about 30 percent of prescriptions written for high blood pressure medications, Whelton said.
Whelton is senior author of a study published in the May 24, 2010, Archives of Internal Medicine that found that using techniques similar to those employed by pharmaceutical sales reps can help persuade doctors to prescribe diuretics.
